This toolkit is designed to assist communities interested in learning how to harness the value of cross-sector collaboration and data sharing to develop a Community Information Exchange (CIE) that enables a network of health, human, and social service providers to deliver coordinated, person-centered care to address social determinants of health to improve population health. 2-1-1 San Diego understands that communities using this toolkit may have very different levels of familiarity with the functions of a CIE and how it can help redefine the health and social care delivery systems to address not only a person’s physical health needs, but also the social impact of determinants of health on individual well-being. This toolkit explains what a CIE is and the key issues a community should consider when developing a CIE.